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Seretide Diskus - 50 mcg / 250 mcg  

Salmeterol + Fluticasone Propionate
Seretide Diskus - 50 mcg / 250 mcg



Seretide is primarily used to treat the symptoms of asthma. Asthma is a medical condition which causes constriction of the air passages in the lungs resulting in difficulty breathing. Breathing difficulties occur when the air passages become inflamed and swollen and the smooth muscles in the air way constrict. As the air passage swell, the muscles tighten restricting air flow further.

The active ingredients contained in Seretide, fluticasone and salmeterol, work together to treat the asthma symptoms. Fluticasone reduces inflammation in the air passages and salmeterol relaxes the muscles in the air passages.
Seretide is a preventative medication and will not stop an asthma attack that is in progress.


Seretide 50 mcg/250mcg is prescribed to control the symptoms caused by asthma. Fluticasone propionate is a corticosteroid that reduces inflammation and salmeterol xinafoate is a beta antagonist that provides long lasting relaxation of the smooth muscles of the air passages.

Seretide works by stimulating the beta two receptors that relax the smooth muscles from the trachea to the bronchioles and reducing inflammation of the air passages in the lungs. The combination of active ingredients works by stopping the production inflammatory cell mediators and increases the bronchi's ability to relax the constricted smooth muscles in the air way decreasing air way swelling and irritation.

Seretide is manufactured by GlaxoSmithKline, UK. The US name brand is Advair Diskus. Seretide is available in the following strengths 50mcg/100mcg, 50 mcg/250 mcg, and 50 mcg/500 mcg. It is available is packs of 60, 120, and 180 doses.

Warnings and Precautions

When using Seretide 50mcg/250 mcg it is important that you follow all of your doctor's instruction. Do not exceed the recommended dosage prescribed by your doctor.
Read the enclosed medication information leaflet for all safety information.
Contact your doctor if you forget to take a dose; do not take a double dose to make up for the missed one.

In case of an accidental overdose, contact your doctor immediately or seek medical attention at the nearest medical facility.
Symptoms of an overdose:

  • Allergic reaction
  • Difficulty breathing
  • Swelling
  • Chest pain or tightness

Do not take this medication is you have any of the following medical conditions:

  • Cardiovascular disease
  • Diabetes
  • Epilepsy
  • Hypertension during pregnancy
  • Myocardial infarction or heart attack
  • Paradoxical respiration

Do not stop, start or change your dosage without checking with your doctor.
Discuss what medication you are taking with your doctor. This includes all prescription, over-the-counter medications, as well as vitamins and herbal supplements.
Do not load the capsule into the Diskus until ready to use.

Seretide may cause dizziness or drowsiness; do not operate machinery until you know how it affects you.
Avoid alcohol consumption.

Avoid contact with people who have infectious illnesses, such as the flu, measles, and chicken pox.
Store this medication in a tightly closed container, out of the reach of children and pets.

Drug Interactions

As is true with most medications, Seretide may interact with other drugs. It is important to tell your doctor what medication you take. This includes all prescription, over-the-counter medications, as well as vitamins and herbal products.

The following is a list of drugs that are known to interact with Seretide:

  • Atenolol or other beta blockers
  • Boceprevir
  • Digitalis
  • Diuretics
  • HIV medications
  • Ketoconazole or other Azole antifungal medications
  • Linezolid
  • Macrolides
  • Nefazodone
  • Sympathomimetics
  • Telithromycin
  • Xanthenes

This is not a complete list of possible drug interactions, your doctor or pharmacist can provide a complete list.

How to use

Your doctor will prescribe the correct dosage for you depending on the severity of your condition. Always follow your doctor's advice for taking Seretide. You should not stop taking or change the dosage amount without checking with your doctor.

The general dosage for asthma symptoms is usually one inhalation two times a day for adults and children over 16 years of age for all strengths. For children 4 to 12 years of age, the generally recommend dosage is Seretide 50 mcg/100 mcg - one inhalation two times a day.

Do not swallow the diskus capsule. Directions for use are as follows:

  • Hold diskus close to mouth
  • Push thumb grip until a click is heard
  • Place diskus mouthpiece near the mouth
  • Slide lever away until it clicks
  • Breathe out, away from device
  • Inhale steadily and deeply on the mouthpiece
  • Remove diskus from mouth and hold the breath for ten seconds
  • Slowly exhale

It is advisable to take the medication at the same time each day. This will help eliminate the chance of forgetting a dose.

Possible Side Effects

Some users may experience side effects when Seretide is used. It is important that you are aware of possible side effects and what to do if you experience any of them. Contact your doctor if you have concerns about yourself or your child.

Not all users will experience a side effect, but if you do stop taking Seretide and contact your doctor immediately.
Some of the common side effects associated with Seretide include:

  • Dizziness
  • Edema
  • Fatigue
  • Fever
  • Headache
  • Hypotension
  • Muscle cramps skin rash
  • Nausea
  • Nose bleeds
  • Pale skin
  • Palpitations
  • Rapid pulse rate
  • Rash
  • Restlessness
  • Sweating
  • Swollen ankles
  • Trembling
  • Urticaria
  • Weakness

More serious side effects include:

  • Chest pain or tightness
  • Irregular heartbeat
  • Skin rash that is lumpy or hives
  • Sudden wheezing
  • Swelling of eyelids, face or lips

Rare and infrequent side effects include:

  • Disturbance in sleep
  • Feeling anxious
  • Increased irritability, primarily in children

If you experience any of the following side effects stop using Seretide and seek medical attention immediately.

Additional Information

SKU 920
US Brand Name Advair Diskus 50 mcg / 250 mcg
Strength 50 mcg / 250 mcg
Generic Name Salmeterol + Fluticasone Propionate
Manufacturer GSK
PharmaceuticalForm Doses
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